Ethylene Glycol Characterization
نویسندگان
چکیده
Ethylene glycol is most commonly found as the primary ingredient of automobile antifreeze and hydraulic brake fluids. The major use of ethylene glycol as an antifreeze is namely in automobiles, in air conditioning systems and in as de-icing fluid for windshields. It is a widely used chemical that is capable of causing significant injury if ingested. It is not intrinsically toxic but requires metabolism. There are various intermediate metabolic products terminating in oxalic acid. Exposure to large amounts of ethylene glycol can damage the kidneys, nervous system, lungs, and heart (21). This noxa has been found in at least 37 of 1,689 National Priorities List sites identified by the Environmental Protection Agency (4). In clinical practice, poisoning with ethylene glycol is common but the number of poisonous subjects in various countries are very different and registered insufficiently. Toxicological The Czech Information Centre answers annualy about sixty acute questions about drinking of ethylene glycol (14). In the Czech Republic adult men are the most endangered segment of the population. Thirty-three poisonous victims were obtained between 2000 and 2002. Three patients died, and 11 patients developed acute renal failure (mean maximum serum creatinine level 618 μmol/L). Upon discharge, serum creatinine levels were still elevated in 10 patients. Antidote ethanol was given in 30 patients. Renal function completely normalized within 20 months after intoxication (13). Ethylene glycol is also a potential agent for chemical terrorism as an ingredient in explosives. Physico-chemical properties, toxicological profile and clinical symptoms of poisoning is discussed in this article.
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